Catalytic Addition of Metallo-Aldehyde Enolates to Ketones: A New C−C Bond-Forming Hydrogenation

• DOI: 10.1021/ol030136c
• Publication Date: 2004-02-26T06:23:02Z
• Authors: Phillip K. Koech; Michael J. Krische
• Keywords: Cationic polymerization; Noyori asymmetric hydrogenation

The first catalytic cross-aldolization of metallo-aldehyde enolates with ketone acceptors is enabled via hydrogenation keto-enals cationic rhodium catalysts. These results, in conjunction prior studies involving the hydrogen-mediated reductive coupling enones, dienes, and diynes carbonyl acceptors, support feasibility developing a broad new class C−C bond formations based on electrophilic trapping intermediates.