Asymmetric Conjugate Addition Reactions of Meldrum's Acid Derived Acceptors Employing Chiral Phosphoramidite Ligands

• DOI: 10.1021/ol035575q
• Publication Date: 2003-11-20T06:09:36Z
• Authors: Takumi Watanabe; Thomas F. Knöpfel; Erick M. Carreira
• Keywords: Phosphoramidite; Conjugate

[reaction: see text] The enantioselective conjugate addition reaction of Et(2)Zn to Meldrum's acid derived acceptors, mediated by a catalyst formed from Cu(O(2)CCF(3))(2) and phosphoramidite ligand, is reported. Adducts are obtained in useful yields up 94% ee.