The First Regioselective Palladium-Catalyzed Indolization of 2-Bromo- or 2-Chloroanilines with Internal Alkynes: A New Approach to 2,3-Disubstituted Indoles

• DOI: 10.1021/ol048114t
• Publication Date: 2004-10-21T04:56:53Z
• Authors: Ming Shen; Guisheng Li; Bruce Z. Lu; Azad Hossain; Frank Roschangar; Vittorio Farina; Chris H. Senanayake
• Keywords: 01 natural sciences; 0104 chemical sciences

The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization 2-bromo- or chloroanilines their derivatives internal alkynes.