A New Entry in Catalytic Alkynylation of Aldehydes and Ketones: Dual Activation of Soft Nucleophiles and Hard Electrophiles by an Indium(III) Catalyst

• DOI: 10.1021/ol050069h
• Publication Date: 2005-03-24T06:17:46Z
• Authors: Ryo Takita; Yuhei Fukuta; Riichiro Tsuji; Takashi Ohshima; Masakatsu Shibasaki
• Keywords: Alkynylation; Dual role

[reaction: see text] A new entry in catalytic alkynylation of carbonyl compounds was developed which dual activation both soft nucleophiles (terminal alkynes) and hard electrophiles (aldehydes ketones) is achieved using an indium(III) catalyst. Preliminary mechanistic studies situ IR NMR spectroscopic analysis are also discussed.