Recoverable Fluorous CBS Methodology for Asymmetric Reduction of Ketones

• DOI: 10.1021/ol051024j
• Publication Date: 2005-07-14T08:58:23Z
• Authors: Zoltán Dalicsek; Ferenc Pollreisz; Ágnes Gömöry; Tibor Soós
• Keywords: Reactivity

An operationally simple and recoverable fluorous CBS methodology was developed. The in situ-generated oxazaborolidine efficiently catalyzed the reduction of ketones with high enantioselectivity reactivity. subsequent recycling prolinol precatalyst achieved by solid-phase extraction.