Synthesis and Biological Evaluation of Manzamine Analogues

• DOI: 10.1021/ol061320b
• Publication Date: 2006-06-29T14:00:09Z
• Authors: Jeffrey D. Winkler; Allyn T. Londregan; Justin R. Ragains; Mark T. Hamann
• Keywords: Antimalarials; Molecular Structure; Plasmodium falciparum; Carbazoles; Drug Resistance; Animals; Chloroquine; 01 natural sciences; Porifera; 0104 chemical sciences; 3. Good health

[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.