Palladium-Catalyzed Oxidative C–H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides

• DOI: 10.1021/ol201201a
• Publication Date: 2011-05-20T17:05:15Z
• Authors: Yinuo Wu; Baozhu Li; Fei Mao; Xingshu Li; Fuk Yee Kwong
• Keywords: Acetanilide; Surface Modification

A palladium-catalyzed oxidative C–H bond functionalization/ortho-acylation of acetanilides using easily accessible aldehyde as the acyl source is described. In presence a Pd(TFA)2 catalyst and tert-butylhydroperoxide at 90 °C in general, an array ortho-acylacetanilides can be afforded good yields.