Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature

• DOI: 10.1021/ol202208b
• Publication Date: 2011-09-12T18:30:26Z
• Authors: Yanchuan Zhao; Weizhou Huang; Ji Zheng; Jinbo Hu
• Keywords: Cleave; Inert; Inert gas

Since 1995, Me3SiCF2H has been widely believed to be an inefficient difluoromethylating agent, which requires harsh reaction conditions cleave its rather inert Si–CF2H bond. However, it now found that, by using a proper Lewis base activator, can efficiently difluoromethylate various aldehydes, ketones, and imines give the corresponding products in good excellent yields at room temperature or even −78 °C.