A Cell-Penetrating Ratiometric Nanoprobe for Intracellular Chloride

in vivo cells 0301 basic medicine 0303 health sciences Molecular Structure Quinolinium Compounds Intracellular Space Silicon Dioxide Cell Line 03 medical and health sciences Chlorides Microscopy, Electron, Transmission Animals Nanoparticles sensor for Chloride
DOI: 10.1021/ol300086w Publication Date: 2012-05-25T19:16:20Z
ABSTRACT
NanoChlor, a nanoparticle-based fluorescent probe for chloride that is both ratiometric and capable of spontaneously penetrating neuronal cells at submillimolar concentrations, was designed and studied. NanoChlor is built on silica nanoparticles grafted with 6-methoxyquinolinium as the chloride-sensitive component and fluorescein as the reference dye. A Stern-Volmer constant of 50 M(-1) was measured in Ringer's buffer at pH 7.2, and the response to chemically induced chloride currents was recorded in real time in hippocampal cells.
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