A Cell-Penetrating Ratiometric Nanoprobe for Intracellular Chloride
in vivo cells
0301 basic medicine
0303 health sciences
Molecular Structure
Quinolinium Compounds
Intracellular Space
Silicon Dioxide
Cell Line
03 medical and health sciences
Chlorides
Microscopy, Electron, Transmission
Animals
Nanoparticles
sensor for Chloride
DOI:
10.1021/ol300086w
Publication Date:
2012-05-25T19:16:20Z
AUTHORS (6)
ABSTRACT
NanoChlor, a nanoparticle-based fluorescent probe for chloride that is both ratiometric and capable of spontaneously penetrating neuronal cells at submillimolar concentrations, was designed and studied. NanoChlor is built on silica nanoparticles grafted with 6-methoxyquinolinium as the chloride-sensitive component and fluorescein as the reference dye. A Stern-Volmer constant of 50 M(-1) was measured in Ringer's buffer at pH 7.2, and the response to chemically induced chloride currents was recorded in real time in hippocampal cells.
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