Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-Catalyzed Enantioselective C–H Bond Activation

• DOI: 10.1021/ol502509f
• Publication Date: 2014-09-23T13:17:36Z
• Authors: Chao Pi; Xiuling Cui; Xiuyan Liu; Mengxing Guo; Hanyu Zhang; Yangjie Wu
• Keywords: Chirality; Planar chirality

The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient concise one-pot conditions up to 85% yield 98% ee. products obtained could be easily converted various chiral ligands via diverse transformations.