Gold(I)-Catalyzed Intermolecular Cycloaddition of Allenamides with α,β-Unsaturated Hydrazones: Efficient Access to Highly Substituted Cyclobutanes

Cyclobutanes Moiety Hydrazone
DOI: 10.1021/ol503121q Publication Date: 2014-11-19T15:40:29Z
ABSTRACT
α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with suitable gold catalyst. The method, which represents the first application of in catalysis, is compatible wide variety substituents at alkenyl moiety hydrazone component, proceeds excellent levels regio- and diastereoselectivity, provides densely substituted cyclobutanes good yields.
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