A Water-Soluble, Small Molecular Fluorescent Sensor with Femtomolar Sensitivity for Zinc Ion

• DOI: 10.1021/ol702192m
• Publication Date: 2007-10-23T10:27:21Z
• Authors: Huan-Huan Wang; Quan Gan; Xiao-Jun Wang; Lin Xue; Sheng-Hua Liu; Hua Jiang
• Keywords: Models, Molecular; Molecular Structure; Water; Crystallography, X-Ray; Sensitivity and Specificity; 01 natural sciences; 0104 chemical sciences; Molecular Weight; Zinc; Solubility; Organometallic Compounds; Fluorescent Dyes

A water-soluble fluorescent sensor, 1, based on the quinoline platform, demonstrates femtomolar sensitivity for zinc ion with a 14-fold enhanced quantum yield upon chelation to zinc ion and also exhibits high selectivity to zinc ion over other physiological relevant divalent metals in the presence of EDTA. X-ray crystal structure of zinc complex reveals that an acetic carboxylic group participates in coordination, which significantly enhances the affinity of 1 for zinc ion.