Tandem Ring-Opening/Closing Reactions of N-Ts Aziridines and Aryl Propargyl Alcohols Promoted by t-BuOK

• DOI: 10.1021/ol802862p
• Publication Date: 2009-02-03T20:46:11Z
• Authors: Liang Wang; Qi-Bin Liu; Duo-Sheng Wang; Xin Li; Xiu-Wen Han; Wen-Jing Xiao; Yong-Gui Zhou
• Keywords: Propargyl; Tandem; Cascade reaction

t-BuOK was found to be an effective promoting reagent for tandem ring-opening/closing reactions of various N-Ts aziridines and aryl propargyl alcohols afford dihydroxazine derivatives in moderate good yields. A plausible reaction mechanism has been proposed.