Catalytic Enantioselective Amination of Enolsilanes Using C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids

• DOI: 10.1021/ol990113r
• Publication Date: 2002-07-26T05:45:00Z
• Authors: David A. Evans; Douglas S. Johnson
• Keywords: Imide

[Cu(S,S)-t-Bu-box](OTf)2 (1) catalyzes the enantioselective amination of enolsilanes with azodicarboxylate derivatives. Isomerically pure aryl ketones, acylpyrroles, and thioesters added to azo-imide in greater than 95% ee. The use an alcohol additive was critical achieving catalyst turnover.