Intermolecular Cross-Coupling of Simple Arenes via C−H Activation by Tuning Concentrations of Arenes and TFA

• DOI: 10.1021/om060889d
• Publication Date: 2006-11-17T12:37:52Z
• Authors: Ruoshi Li; Li Jiang; Wenjun Lu
• Keywords: 01 natural sciences; 0104 chemical sciences

Formation of unsymmetrical biaryls from simple arenes has been achieved successfully in a catalytic system Pd(OAc)2/CF3CO2H(TFA)/K2S2O8 just by tuning the concentrations and TFA under mild conditions. A proposed mechanism containing two-step aromatic C−H activation on this novel intermolecular cross-coupling is also suggested partly supported experiments.