A Convenient and Stable Synthon for Ethyl Azide and Its Evaluation in a [3 + 2]-Cycloaddition Reaction under Continuous-Flow Conditions

• DOI: 10.1021/op900078t
• Publication Date: 2009-05-28T15:15:03Z
• Authors: Rob Tinder; Roger Farr; Richard Heid; Ralph Zhao; Randy S. Rarig; Thomas Storz
• Keywords: Synthon; Cyanoacetamide

Azidoethyl phenyl sulfide, a readily accessible and reasonably stable synthon for ethyl azide with acceptable thermal safety properties, was investigated in preliminary design space evaluation of [3 + 2]-cycloaddition cyanoacetamide under continuous-flow conditions the Syrris AFRICA flow reactor.