Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks

Metabolic pathway Metabolic activity
DOI: 10.1021/pr800353t Publication Date: 2008-11-11T14:01:22Z
ABSTRACT
Histopathologically well-characterized fish liver was analyzed by 800 MHz 1H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were multivariate statistics correlation networks, results revealed elevated anaerobic metabolism reduced choline in Significant negative correlations observed alanine-acetate (p = 3.0 × 10−5) proline-acetate 0.003) tumors only, suggesting alanine proline are utilized as alternative energy sources flatfish tumors.
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