Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks
Adenoma
Proteomics
0303 health sciences
Magnetic Resonance Spectroscopy
Proteome
Liver Neoplasms
Computational Biology
Environment
7. Clean energy
Choline
Gene Expression Regulation, Neoplastic
03 medical and health sciences
Liver
Flatfishes
Animals
Metabolomics
False Positive Reactions
DOI:
10.1021/pr800353t
Publication Date:
2008-11-11T14:01:22Z
AUTHORS (6)
ABSTRACT
Histopathologically well-characterized fish liver was analyzed by 800 MHz 1H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were analyzed by multivariate statistics and metabolic correlation networks, and results revealed elevated anaerobic metabolism and reduced choline metabolism in tumor tissue. Significant negative correlations were observed between alanine-acetate (p = 3.0 x 10(-5)) and between proline-acetate (p = 0.003) in tumors only, suggesting alanine and proline are utilized as alternative energy sources in flatfish liver tumors.
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