Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks

• DOI: 10.1021/pr800353t
• Publication Date: 2008-11-11T14:01:22Z
• Authors: Andrew D. Southam; John M. Easton; Grant D. Stentiford; Christian Ludwig; Theodoros N. Arva...; Mark R. Viant
• Keywords: Metabolic pathway; Metabolic activity

Histopathologically well-characterized fish liver was analyzed by 800 MHz 1H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were multivariate statistics correlation networks, results revealed elevated anaerobic metabolism reduced choline in Significant negative correlations observed alanine-acetate (p = 3.0 × 10−5) proline-acetate 0.003) tumors only, suggesting alanine proline are utilized as alternative energy sources flatfish tumors.