Gastroesophageal reflux disease in lung transplant recipients

• DOI: 10.1034/j.1399-0012.2003.00060.x
• Publication Date: 2003-07-18T07:48:39Z
• Authors: Denis Hadjiliadis; R Duane Davis; Mark P Steele; Robert H Messier; Christine L Lau; Steve S Eubanks; Scott M Palmer
• Keywords: Supine position

Chronic allograft dysfunction after lung transplantation contributes to poor long-term survival. A link between gastric aspiration and post-transplant has been suggested, but little is known about the significance of gastroesophageal reflux disease (GERD) transplantation.A retrospective study was performed determine prevalence GERD in transplant recipients. Patients who underwent at Duke University, survived least 6 months had 24-h pH studies were included analysis. Antireflux medications discontinued prior study. Demographic data, date results, FEV1 time study, confirmed acute rejection episodes, current collected. The ratio calculated (current FEV1/best FEV1).Forty-three patients met entry criteria. Studies a median 558 d post-transplant. Thirty forty-three (69.8%) tested abnormal total acid contact times (normal: <5%). mean for all 10% total, 11.8% upright 7.9% supine. negative correlation found or (-0.341 -0.419; p = 0.025 0.005, respectively). effect on remained significant multivariable analysis.There high among selected recipients its presence associated with worse pulmonary function. Future are needed assess whether pathogenesis bronchiolitis obliterans syndrome (BOS).