HLA‐A and ‐B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais

• DOI: 10.1034/j.1399-0039.2002.600405.x
• Publication Date: 2003-03-12T20:58:29Z
• Authors: H.A.F. Stephens; R. Klaythong; M. Sirikong; D.W. Vaughn; S. Green; S. Kalayanarooj; T.P. Endy; D.H. Libraty; A. Nisalak; B.L. Innis; A.L. Rothman; F.A. Ennis; D. Chandanayingyong
• Keywords: Thais

Abstract: Little is known of the role classical HLA‐A and ‐B class I alleles in determining resistance, susceptibility, or severity acute viral infections. Appropriate paradigms for immunogenetic studies infections are dengue fever (DF) hemorrhagic (DHF). Both primary secondary with virus (DEN) serotypes 1, 2, 3 4, can result either clinically less severe DF more DHF. In exposures, a memory response induced immunologically primed individuals, which both clear infecting contribute to its pathology. case–control study 263 ethnic Thai patients infected DEN‐1, ‐2, ‐3 ‐4, we detected HLA associations infections, but not naive HLA‐A*0203 was associated DF, regardless serotype. By contrast, HLA‐A*0207 susceptibility DHF DEN‐1 DEN‐2 only. Conversely, HLA‐B*51 development HLA‐B*52 Moreover, HLA‐B44, B62, B76 B77 also appeared be protective against developing clinical disease after infection. These results confirm that outcome exposure virus, previously exposed individuals.