Six minute walking distance in healthy elderly subjects

• DOI: 10.1034/j.1399-3003.1999.14b06.x
• Publication Date: 2003-03-11T20:11:46Z
• Authors: T. Troosters; R. Gosselink; M Decramer
• Keywords: Distance running; Power walking

Age-related memory impairments have been associated with structural changes in the dopaminergic system, but underlying mechanisms remain unclear. Recent work indicates that iron accumulation might be of particular relevance. As accumulates, a degeneration myelin sheaths has observed elderly, relationship between both and their impact on performance healthy elderly humans important open questions. To address this issue, we combined an established behavioral paradigm to test [verbal learning (VLMT)] state art quantitative magnetic resonance imaging techniques allowing us quantify degree myelination via markers tissue microstructure group young (18–32 years) (55–79 years). expected, decrease gray matter volume myelin, increase relative subjects within widespread brain regions, including basal ganglia. Furthermore, higher levels ventral striatum were accompanied by negative correlation specific for participants. Importantly, (and ratio) predicted VLMT. This suggests is linked demyelination declarative memory. Together, our data provide novel insights into microstructural decline elderly. <b>SIGNIFICANCE STATEMENT</b> Memory common phenomenon, neural We used approach allowed combine behavior whole-brain measures iron, participant9s individual subspace analyze structure–structure structure–behavior interactions. able show, age-related high are striatum, which performance. such, findings unprecedented basic