Detection of Fel d 1–immunoglobulin G immune complexes in cord blood and sera from allergic and non‐allergic mothers

• DOI: 10.1034/j.1399-3038.2001.012002059.x
• Publication Date: 2002-07-26T07:51:43Z
• Authors: Rosaura Casas; Bengt Björkstén
• Keywords: Cord blood; Priming (agriculture)

It is an established fact that T‐cell responses of fetal origin to inhalant allergens are present in most cord blood samples. These immune could be explained by trans‐placental passage peptides, either as free antigens or complexes with immunoglobulin G (IgG), providing the fetus a trigger for priming system already utero . The aim this study was investigate presence major cat allergen, Fel d 1, IgG and maternal sera. Serum samples from 75 mothers (38 allergic, 37 non‐allergic), their infants, were investigated 1–IgG (ICs) using amplified enzyme‐linked immunosorbent assay (ELISA). Three monoclonal antibodies 1 used coating. specificity method confirmed inhibition experiments. ICs detected sera 45% allergic 49% non‐allergic mothers, in, respectively, 34% 41% infants. Therefore, neither prevalence nor level affected allergy. Low levels trans‐placentally transferred can provide signal allergens. However, not necessarily related disease.