Peripheral delivery of a ROCK inhibitor improves learning and working memory.

• DOI: 10.1037/a0014260
• Publication Date: 2009-01-26T19:01:22Z
• Authors: Matthew J. Huente...; Dietrich A. Stephan; Joshua Talboom; Jason J. Corneveaux; David M. Reiman; Jill D. Gerber; Carol A. Barnes; Gene E. Alexander; Eric M. Reiman; Heather A. Bimont...
• Keywords: Association (psychology)

Previously, utilizing a series of genome-wide association, brain imaging and gene expression studies we implicated the KIBRA RhoA/ROCK pathway in hippocampal-mediated human memory.Here show that peripheral administration ROCK inhibitor hydroxyfasudil improves spatial learning working memory rodent model.This study supports action on memory, suggests potential value inhibition for promotion cognition humans highlights powerful unbiased association to inform novel uses existing pharmaceuticals.