Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: A randomized controlled trial.

• DOI: 10.1037/a0020335
• Publication Date: 2010-07-26T18:01:48Z
• Authors: Marijn de Bruin; Harm J. Hospers; Gerard J. P. van ...; Gerjo Kok; William M. Koevoets; Jan M. Prins
• Keywords: Adult; Counseling; Male; improve adherence; protease inhibitors; HIV Infections; outcomes; Young Adult; 03 medical and health sciences; medications; 0302 clinical medicine; Surveys and Questionnaires; Humans; care; interventions; Drug Packaging; clinical-trials; Aged; Netherlands; antiretroviral therapy adherence; Middle Aged; Viral Load; failure; viral load; 3. Good health; Treatment Outcome; Anti-Retroviral Agents; Patient Compliance; Female; Drug Monitoring; Follow-Up Studies; Program Evaluation

To investigated the effectiveness of an adherence intervention (AIMS) designed to fit HIV-clinics' routine care procedures.Through block randomization, patients were allocated or control group. The study included 2 months baseline measurement, 3 intervention, and 4 follow-up. HIV-nurses delivered a minimal ("adherence sustaining") scoring >95% at baseline, intensive improving") with <95% adherence. Control participants received high-quality usual care.Electronically monitored viral load.133 (67 control, 66 intervention), 60% had 87% (116/133) completed trial. Intent-to-treat analyses showed that improved significantly in complete sample. Subgroup this effect was caused by (mean difference = 15.20%; p < .001). These effects remained stable during number undetectable load increased group compared (OR 2.96, .05). Treatments on mediated improvements adherence.The AIMS-intervention effective can be integrated clinical for HIV-infected patients. Future research should its (cost)effectiveness among more heterogeneous samples settings variable levels standard care.