Decreased reward-related brain function prospectively predicts increased substance use.

• DOI: 10.1037/abn0000711
• Publication Date: 2021-11-29T16:25:11Z
• Authors: Corinne P. Bart; Robin Nusslock; Tommy H. Ng; Madison K. Titone; Ann L. Carroll; Katherine S. F. D...; Christina B. Young; Casey C. Armstrong; Jason Chein; Lauren B. Alloy
• Keywords: Ventral striatum; Orbitofrontal cortex; Brain stimulation reward; Reward system; Brain mapping

Substance use and addiction are prominent global health concerns associated with abnormalities in reward sensitivity. Reward sensitivity approach motivation supported by a fronto-striatal neural circuit including the orbitofrontal cortex (OFC), ventral striatum (VS), dorsal (DS). Although research highlights circuitry among individuals problematic substance use, questions remain about whether such arises from excessively high, or low, This study examined reward-related brain function predicted subsequent course. Participants were 79 right-handed (