Independent and joint association of obesity and metabolic syndrome with depression and inflammation.

• DOI: 10.1037/hea0000764
• Publication Date: 2019-05-23T13:43:08Z
• Authors: Kasra Moazzami; Bruno B. Lima; Samaah Sullivan; Amit Shah; J. Douglas Bremner; Viola Vaccarino
• Keywords: Depression

OBJECTIVE To investigate the separate and combined associations of obesity metabolic syndrome (MetS) with depression role inflammation. METHOD Depression was assessed Patient Health Questionnaire-9 (PHQ-9) defined a cutpoint ≥10. Obesity as body mass index (BMI) ≥30 kg/m2 from measured height weight. MetS based on American Heart Association consensus definition. Participants were divided into four groups: healthy normal weight (MHN), metabolically obese (MHO), unhealthy (MUN), (MUO). C-Reactive protein in subsample. RESULTS A total 18,025 subjects included analysis. MUO had highest prevalence compared MHN group (14.8% vs. 6.8, p < .001). While both independently associated depression, there significant interaction between two (p .001), indicating that synergistic. After adjusting for baseline characteristics, group, odds (odds ratio [OR] = 2.30, 95% CI [2.03, 2.61]), followed by MHO (OR 1.51, [1.30, 1.74]) MUN 1.39, [1.18, 1.64]). The also showed level C-reactive protein, latter partially mediated effect depressive symptoms (20.5% effect). CONCLUSION Both are independent each other, but when present together, these conditions have synergistic association depression. (PsycINFO Database Record (c) 2019 APA, all rights reserved).