Initial application of a human laboratory model for estimating the motivational substitutability of e-cigarettes for combustible cigarettes.

• DOI: 10.1037/pha0000237
• Publication Date: 2019-01-28T16:26:36Z
• Authors: Adam M. Leventhal; Nicholas I. Golde...; Claudia G. Aguirre; Jimi Huh; Matthew G. Kirkpa...
• Keywords: Anhedonia; Tobacco product

This pilot study tested a novel human laboratory model for estimating the extent to which electronic cigarettes (e-cigarettes) serve as motivational substitutes combustible cigarettes. The assesses 3 parameters of substitutability, including the: (a) increase in reward value e-cigarettes after tobacco deprivation; (b) reduction e-cigarette administration; and (c) comparability withdrawal-suppressing effects versus Dual users (daily smokers, vaped 4+ days/week, M age = 35.3) attended 4 visits 16-h product abstinence. For 2 visits, participants completed withdrawal measures task assessing smoking's preceded by either: satiation vaping or sustained deprivation. other vaping's continued deprivation smoking. Tobacco (vs. smoking) increased value, indicated nonsignificantly greater likelihood initiating abstaining money (d -.26; adjusted p [padj] .08) more episodes purchased (β .22; padj .08). Satiation deprivation) reduced smoking initiation .46; .09) significantly decreased number -.29; .04). Relative deprivation, suppressed withdrawal-related negative affect, vape urge, anhedonia (ds ≥ .54). magnitude vaping-induced smoking-induced suppression did not differ all outcomes than was strongly -1.57) -.64). Future application extension this may advance regulatory science policy addressing use among smokers. (PsycINFO Database Record 2019 APA, rights reserved).