Noninvasive visualization of tumors in rodent dorsal skin window chambers

• DOI: 10.1038/13736
• Publication Date: 2002-07-26T08:47:57Z
• Authors: Qian Huang; Siqing Shan; Rod D. Braun; Jennifer Lanzen; Gopal Anyrhambatla; Garheng Kong; Michael Borelli; Peter Corry; Mark W. Dewhirst; Chuan-Yuan Li
• Keywords: Skin Window Technique; 0301 basic medicine; Mice; 03 medical and health sciences; Animals; Antineoplastic Agents; Genetic Therapy; Neoplasms, Experimental; Rats; 3. Good health

Advances in molecular biology and combina-torial chemistry have ushered in a new era of“rational” drug design for cancer treatment.With the Human Genome Project promisingto further accelerate the already rapid pace oftherapeutics development by providing anever-larger assortment of potential targets, itis becoming increasingly important to be ableto evaluate therapeutic candidates in a timelyand discriminate fashion. However, goodexperimental models for evaluating therapeu-tic candidates have been lacking, especially inareas that target tumors indirectly, such asantiangiogenesis or vascular targeting agents.The National Cancer Institute 60-cellpanel