TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus

• DOI: 10.1038/14724
• Publication Date: 2002-07-26T08:33:27Z
• Authors: T. B. Usdin; S. R. J. Hoare; T. Wang; É. Mezey; J. A. Kowalak
• Keywords: 0303 health sciences; 03 medical and health sciences; Neuropeptides; Hypothalamus; Animals; Humans; Receptors, Parathyroid Hormone; Rats

Activation by parathyroid hormone (PTH)1 and peripheral distribution2,3 the of PTH2 receptor (PTH2-R) are well described. Highest expression of PTH2-R is found in the brain1, where PTH synthesis is undetectable. We have now purified and sequenced a new polypeptide from bovine hypothalamus (referred to here as tuberoinfundibular peptide of 39 residues; TIP39), a potent and selective agonist at the PTH2-R. The PTH2-R was highly expressed in hypothalamic areas that regulate pituitary hormone secretion and spinal cord regions involved in pain perception.