Cyclic Nucleotides as Intracellular Mediators of the Expression of Antigen-sensitive Cells

• DOI: 10.1038/246405a0
• Publication Date: 2005-08-03T07:46:20Z
• Authors: JAMES WATSON; RUTH EPSTEIN; MELVIN COHN
• Keywords: Mediator

The interaction of antigen with antigen-sensitive cells can lead to antibody synthesis (induction) or can render these cells non-inducible (paralysis). Cyclic AMP may be the intracellular mediator of a paralytic signal whereas both cyclic AMP and cyclic GMP may be required as mediators of an inductive signal.