Glycyrrhizic acid inhibits virus growth and inactivates virus particles

• DOI: 10.1038/281689a0
• Publication Date: 2005-08-02T10:45:00Z
• Authors: Raffaello Pompei; Ornella Flore; Maria Antonietta ...; Alessandra Pani; Bernardo Loddo
• Keywords: Cytopathology; Glycyrrhiza

Screening investigations in antiviral action of plant extracts have revealed that a component of Glycyrrhiza glabra roots, found to be glycyrrhizie acid, is active against viruses. We report here that this drug inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.