Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

• DOI: 10.1038/304035a0
• Publication Date: 2004-11-17T23:19:56Z
• Authors: Michael D. Waterf...; Geoffrey T. Scrace; Nigel Whittle; Paul Stroobant; Ann Johnsson; Åke Wasteson; Bengt Westermark; Carl-Henrik Heldin; Jung San Huang; Thomas F. Deuel
• Keywords: Platelet-Derived Growth Factor; 0301 basic medicine; Genes, Viral; Macromolecular Substances; Sarcoma Virus, Woolly Monkey; Oncogene Proteins v-sis; Nucleic Acid Hybridization; Oncogenes; 3. Good health; Molecular Weight; Viral Proteins; 03 medical and health sciences; Cell Transformation, Neoplastic; Retroviridae; Genes; Animals; Humans; Amino Acid Sequence; RNA, Messenger; Growth Substances; Peptides

A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.