A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes

• DOI: 10.1038/319291a0
• Publication Date: 2004-11-18T04:00:08Z
• Authors: François Rouyer; Marie-Christine S...; Christophe Johnsson; Gilles Vergnaud; Howard J. Cooke; Jean Weissenbach
• Keywords: Pseudoautosomal region; Chromosomal crossover; Genetic linkage; Linkage (software); Sex linkage

Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.