A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

• DOI: 10.1038/326042a0
• Publication Date: 2003-06-12T21:14:52Z
• Authors: Yoav Citri; Hildur V. Colot; Agnes C. Jacquier; Qiang Yu; Jeffrey C. Hall; David Baltimore; Michael Rosbash
• Keywords: Cloning (programming); splice

Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of the cloned cDNAs can restore clock function to mutant arrhythmic flies.