Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

• DOI: 10.1038/377397a0
• Publication Date: 2003-06-12T23:57:07Z
• Authors: Andreas J. Hörlein; Anders M. Näär; Thorsten Heinzel; Joseph Torchia; Bernd Gloss; Riki Kurokawa; Aimee Ryan; Yasutomi Kamei; Mats Söderström; Christopher K. Glass; Michael G. Rosenfeld
• Keywords: Thyroid hormone receptor; PELP-1

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.