Noninvasive Assessment of Endothelial Function in the Skin Microcirculation

• DOI: 10.1038/ajh.2010.10
• Publication Date: 2010-02-18T15:04:11Z
• Authors: H. Debbabi; P. Bonnin; P. H. Ducluzeau; G. Leftheriotis; B. I. Levy
• Keywords: Brachial artery; Endothelial Dysfunction

The structure and function of blood vessels varies along the vascular tree. Endothelial dysfunction is a hallmark increased cardiovascular (CV) risk that can be assessed by several methods, some which are invasive restricted application. aim this study was to determine whether laser Doppler response skin microcirculation acetylcholine, reflects conduit artery brachial flow-mediated dilation (FMD).Noninvasive measurement endothelium-dependent vasodilation in flowmetry (LDF) local transdermal iontophoretic application acetylcholine (Ach-SkBF) an operator-independent method. Ach-SkBF FMD were measured nondominant upper limb 55 unselected consecutive patients admitted our department for evaluation CV factors.Ach-SkBF (mean +/- s.d. (min-max)) 490 414%, (10-1667%) 3.77 3.01% (0.91-10.91). A strong linear relationship found between FMD: = 122.7 + 25.8 (r 0.92, P < 0.0001).Endothelial dilatory flow similar large arteries microvasculature. Thus, changes using LDF coupled with iontophoresis represents technically challenging reliable noninvasive method assessment endothelial within range normal altered endothelium responses.