MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST

• DOI: 10.1038/cddis.2016.100
• Publication Date: 2016-04-21T12:50:12Z
• Authors: L K Zhuang; Y T Yang; X Ma; B Han; Z S Wang; Q Y Zhao; L Q Wu; Z Q Qu
• Keywords: XIST; Tumor progression

Abstract MicroRNA (miRNA) and long non-coding RNA (lncRNA) have been demonstrated to participate in the progression of many cancers. Hepatocellular carcinoma (HCC) is one most common aggressive malignant tumors worldwide, while molecular mechanisms underlying HCC tumorigenesis are not completely clear. In this study, we showed that miR-92b was significantly upregulated tumor tissue plasma patients, its expression level highly correlated with gender microvascular invasion. Functionally, could promote cell proliferation metastasis vitro vivo . Mechanistic investigations suggested Smad7, which exhibited an inverse relationship HCC, a direct target reverse effects on tumorigenesis. Furthermore, X-inactive specific transcript (XIST) directly interact repress each other, XIST inhibit by targeting miR-92b. Taken together, our study only revealed for first time importance XIST/miR-92b/Smad7 signaling axis but also potential value as biomarker clinical diagnosis treatment HCC.