Erythropoietin protects against rhabdomyolysis-induced acute kidney injury by modulating macrophage polarization

• DOI: 10.1038/cddis.2017.104
• Publication Date: 2017-04-06T16:40:50Z
• Authors: Shuo Wang; Chao Zhang; Jiawei Li; Sidikejiang Niyazi; Long Zheng; Ming Xu; Ruiming Rong; Cheng Yang; Tongyu Zhu
• Keywords: Macrophage polarization

Abstract Erythropoietin (EPO) is a well-known hormone that clinically used for the treatment of anemia. Very recently, an increasing body evidence showed EPO could still regulate bioactivities macrophages. However, details about immunomodulatory effect on macrophages are not fully delineated, particularly in setting renal damages. Therefore, present study, we determined whether exert impact dynamics well-established model rhabdomyolysis-induced acute kidney injury and explored potential mechanisms. was found to ameliorate injuries by reducing recruitment promoting phenotype switch toward M2 vivo . It also confirmed directly suppress pro-inflammatory responses M1 promote marker expression vitro Data indicated possible involvement Jak2/STAT3/STAT6 pathway augmentation polarization. These results improved understanding immunoregulatory capacity macrophages, which might optimize therapeutic modalities EPO.