Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface
Interface (matter)
DOI:
10.1038/celldisc.2017.5
Publication Date:
2017-03-28T12:59:11Z
AUTHORS (18)
ABSTRACT
Abstract Astrocytes send out long processes that are terminated by endfeet at the vascular surface and regulate functions as well homeostasis interface. To date, astroglial mechanisms underlying these have been poorly addressed. Here we demonstrate a subset of messenger RNAs is distributed in astrocyte endfeet. We identified, among this transcriptome, pool bound to ribosomes, endfeetome, primarily encodes for secreted membrane proteins. detected nascent protein synthesis Finally, determined presence smooth rough endoplasmic reticulum Golgi apparatus perivascular endfeet, suggesting local maturation These results first time occurs distal may sustain their structural functional polarization
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