Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface

• DOI: 10.1038/celldisc.2017.5
• Publication Date: 2017-03-28T12:59:11Z
• Authors: Anne- Cécile Boulay; Bruno Saubaméa; Nicolas Adam; Stéphanie Chassei...; Noémie Mazaré; Alice Gilbert; Mathieu Bahin; Leïla Bastianelli; Corinne Blugeon; Sandrine Perrin; Juliette Pouch; Bertrand Ducos; Stéphane Le Crom; Auguste Genovesio; Fabrice Chrétien; Xavier Declèves; Jean-Louis Laplanche; Martine Cohen-Salmon
• Keywords: Interface (matter)

Abstract Astrocytes send out long processes that are terminated by endfeet at the vascular surface and regulate functions as well homeostasis interface. To date, astroglial mechanisms underlying these have been poorly addressed. Here we demonstrate a subset of messenger RNAs is distributed in astrocyte endfeet. We identified, among this transcriptome, pool bound to ribosomes, endfeetome, primarily encodes for secreted membrane proteins. detected nascent protein synthesis Finally, determined presence smooth rough endoplasmic reticulum Golgi apparatus perivascular endfeet, suggesting local maturation These results first time occurs distal may sustain their structural functional polarization