CD4+ T cells memorize obesity and promote weight regain

• DOI: 10.1038/cmi.2017.36
• Publication Date: 2017-06-19T08:40:29Z
• Authors: Jianghuan Zou; Beibei Lai; Mingzhu Zheng; Qin Chen; Shujun Jiang; Anying Song; Zan Huang; Peiliang Shi; Xin Tu; Di Wang; Linrong Lu; Zhaoyu Lin; Xiang Gao
• Keywords: Memorization

Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown. In this study, we report that immune cells, especially CD4+ T mediate 'memory' previous obese status. a gain-loss-regain model, found C57BL/6J mice with an history showed much faster rate body regain. This memory could last for at least 2 months after previously were kept same as non-obese mice. Surprisingly, such was abrogated by dexamethasone treatment, whereas immunodeficient Rag1-/- and H2A-/- failed to establish memory. repossessed when cells or isolated from transferred. Furthermore, depletion led ablation. Taken together, conclude promote