The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages

• DOI: 10.1038/emi.2016.136
• Publication Date: 2017-01-18T08:23:18Z
• Authors: Jingyuan Liu; Yulan Sun; Weifeng Shi; Shuguang Tan; Yang Pan; Shujuan Cui; Qingchao Zhang; Xiangfeng Dou; Yanning Lv; Xinyu Li; Xitai Li; Lijuan Chen; Chuansong Quan; Qianli Wang; Yingze Zhao; Qiang lv; Wenhao Hua; Hui Zeng; Zhihai Chen; Haofeng Xiong; Chengyu Jiang; Xinghuo Pang; Fujie Zhang; Mifang Liang; Guizhen Wu; George F Gao; William J Liu; Ang Li; Quanyi Wang
• Keywords: Reassortment; Rift Valley Fever; Lineage (genetic)

We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection new reassortant different lineages viruses (RVFVs). developed multiorgan dysfunction and gradually recovered continuous renal replacement therapy short regimen methylprednisolone treatment. disordered cytokines chemokines plasma revealed hypercytokinemia, but levels protective were low upon admission fluctuated as disease improved. Whole-genome sequencing phylogenetic analysis that strain was comprising L M genes lineage E S gene A. This highlights RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks pose serious threat to global public health well livestock breeding industry.