The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages
0301 basic medicine
China
Livestock
Genes, Viral
Rift Valley Fever
hypercytokinemia
Infectious and parasitic diseases
RC109-216
Genome, Viral
Microbiology
Methylprednisolone
imported case
03 medical and health sciences
Animals
Humans
Phylogeny
Travel
0303 health sciences
Genetic Variation
Middle Aged
Viral Load
Rift Valley fever virus
QR1-502
3. Good health
Angola
Cytokines
RNA, Viral
reassortment
Original Article
Chemokines
Tomography, X-Ray Computed
Reassortant Viruses
DOI:
10.1038/emi.2016.136
Publication Date:
2017-01-18T08:23:18Z
AUTHORS (29)
ABSTRACT
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.
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