The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages

0301 basic medicine China Livestock Genes, Viral Rift Valley Fever hypercytokinemia Infectious and parasitic diseases RC109-216 Genome, Viral Microbiology Methylprednisolone imported case 03 medical and health sciences Animals Humans Phylogeny Travel 0303 health sciences Genetic Variation Middle Aged Viral Load Rift Valley fever virus QR1-502 3. Good health Angola Cytokines RNA, Viral reassortment Original Article Chemokines Tomography, X-Ray Computed Reassortant Viruses
DOI: 10.1038/emi.2016.136 Publication Date: 2017-01-18T08:23:18Z
ABSTRACT
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.
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