Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration

• DOI: 10.1038/eye.2015.64
• Publication Date: 2015-05-15T09:33:20Z
• Authors: K O Akuffo; J M Nolan; A N Howard; R Moran; J Stack; R Klein; B E Klein; S M Meuer; S Sabour-Pickett; D I Thurnham; S Beatty
• Keywords: Age-related maculopathy

To compare the impact of sustained supplementation using different macular carotenoid formulations on pigment (MP) and visual function in early age-related degeneration (AMD). Sixty-seven subjects with AMD were randomly assigned to: Group 1 (20 mg per day lutein (L), 0.86 zeaxanthin (Z); Ultra Lutein), 2 (10 meso-zeaxanthin (MZ), 10 L, Z; Macushield; Macuhealth), 3 (17 MZ, Z). MP was measured customised heterochromatic flicker photometry assessed by measuring contrast sensitivity (CS) best-corrected acuity (BCVA). graded Wisconsin Age-Related Maculopathy Grading System (AREDS 11-step severity scale). At years, a significant increase from baseline observed all groups at each eccentricity (P<0.05), except 1.75° (P=0.160). Between 24 36 months, increases seen (P<0.05 for all), 0.50° whereas no (P>0.05 all). compared baseline, following improvements (P<0.05) CS observed: 2—1.2, 6, 9.6 cycles degree (c.p.d.); 1—15.15 c.p.d.; 3—6, 9.6, 15.15 c.p.d. No changes BCVA, or progression to advanced AMD, observed. In can be augmented variety supplements, although inclusion MZ may confer benefits terms panprofile augmentation enhancement.