One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms

• DOI: 10.1038/ijos.2016.13
• Publication Date: 2016-06-03T09:28:08Z
• Authors: Lei Cheng; Ke Zhang; Chen-Chen Zhou; Michael D Weir; Xue-Dong Zhou; Hockin H K Xu
• Keywords: Amorphous calcium phosphate

Dental composites are commonly used restorative materials; however, secondary caries due to biofilm acids remains a major problem. The objectives of this study were (1) develop composite containing quaternary ammonium dimethacrylate (QADM), nanoparticles silver (NAg), and amorphous calcium phosphate (NACP), (2) conduct the first investigation mechanical properties, response acid production vs water-ageing time from 1 day 12 months. A 4 × 5 design was utilized, with four (NACP-QADM composite, NACP-NAg NACP-QADM-NAg commercial control composite), five periods (1 day, 3, 6, 9, months). After each period, properties resins measured in three-point flexure, antibacterial tested via dental plaque model using human saliva as an inoculum. months water-ageing, had flexural strength elastic modulus matching those (P>0.1). Incorporation QADM or NAg into NACP greatly reduced viability, metabolic activity production. both possessed stronger capability than one alone (P<0.05). anti-biofilm maintained after showed no significant decrease increasing In conclusion, decreased viability lactic production, while load-bearing composite. There its year water-ageing. durable indicate that may be useful restorations combat caries. Antibacterial improve on addition nano-silver compound. Amorphous is widely for restoration because biocompatibility similar composition minerals hard tissues. However, detrimental formation biofilms hence, promotion caries, problems. Hockin Xu at University Maryland, US, Xuedong Zhou Sichuan University, China, monitored range assess effects adding dimethylacrylate. Both additives well over year. Moreover, incorporated significantly enhanced compared single additive. composites' not compromised by additive incorporation.