A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities

• DOI: 10.1038/ismej.2015.11
• Publication Date: 2015-02-03T15:30:51Z
• Authors: Jiachao Zhang; Zhuang Guo; Zhengsheng Xue; Zhihong Sun; Menghui Zhang; Lifeng Wang; Guoyang Wang; Fang Wang; Jie Xu; Hongfang Cao; Haiyan Xu; Qiang Lv; Zhi Zhong; Yongfu Chen; Sudu Qimuge; Bilige Menghe; Yi Zheng; Liping Zhao; Wei Chen; Heping Zhang
• Keywords: UniFrac

Abstract Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular symbionts maintaining health their hosts. Here we performed a large structural survey fecal in 314 young adults, covering 20 rural urban cohorts from 7 ethnic groups living 9 provinces throughout China. Canonical analysis unweighted UniFrac principal coordinates clustered subjects mainly ethnicities/geography less so lifestyles. Nine predominant genera, all which are known to contain short-chain fatty acid producers, co-occurred individuals collectively represented nearly half total sequences. Interestingly, species-level compositional profiles within these nine genera still discriminated according Therefore, phylogenetically diverse core at genus level may be commonly shared distinctive as functionally indispensable service providers