Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico

Adult Male 0301 basic medicine Adolescent Environmental Exposure Methyltransferases Middle Aged Polymorphism, Single Nucleotide 01 natural sciences Arsenic 3. Good health Young Adult 03 medical and health sciences Diabetes Mellitus Prevalence Humans Female Mexico 0105 earth and related environmental sciences
DOI: 10.1038/jes.2012.103 Publication Date: 2012-10-24T10:41:28Z
ABSTRACT
Exposure to arsenic in drinking water is associated with increased prevalence of diabetes. We previously reported an association of diabetes and urinary concentration of dimethylarsinite (DMAsIII), a toxic product of arsenic methylation by arsenic ( +3 oxidation state) methyltransferase (AS3MT). Here we examine associations between AS3MT polymorphism, arsenic metabolism and diabetes. Fasting blood glucose, oral glucose tolerance and self-reported diagnoses were used to identify diabetic individuals. Inorganic arsenic and its metabolites were measured in urine. Genotyping analysis focused on six polymorphic sites of AS3MT. Individuals with M287T and G4965C polymorphisms had higher levels of urinary DMAsIII and were more frequently diabetic than the respective wild-type carriers, although the excess was not statistically significant. Odds ratios were 11.4 (95% confidence interval (CI) 2.2–58.8) and 8.8 (95% CI 1.6–47.3) for the combined effects of arsenic exposure >75th percentile and 287T and 4965C genotypes, respectively. Carriers of 287T and 4965C may produce more DMAsIII and be more likely to develop diabetes when exposed to arsenic.
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