Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico
Adult
Male
0301 basic medicine
Adolescent
Environmental Exposure
Methyltransferases
Middle Aged
Polymorphism, Single Nucleotide
01 natural sciences
Arsenic
3. Good health
Young Adult
03 medical and health sciences
Diabetes Mellitus
Prevalence
Humans
Female
Mexico
0105 earth and related environmental sciences
DOI:
10.1038/jes.2012.103
Publication Date:
2012-10-24T10:41:28Z
AUTHORS (7)
ABSTRACT
Exposure to arsenic in drinking water is associated with increased prevalence of diabetes. We previously reported an association of diabetes and urinary concentration of dimethylarsinite (DMAsIII), a toxic product of arsenic methylation by arsenic ( +3 oxidation state) methyltransferase (AS3MT). Here we examine associations between AS3MT polymorphism, arsenic metabolism and diabetes. Fasting blood glucose, oral glucose tolerance and self-reported diagnoses were used to identify diabetic individuals. Inorganic arsenic and its metabolites were measured in urine. Genotyping analysis focused on six polymorphic sites of AS3MT. Individuals with M287T and G4965C polymorphisms had higher levels of urinary DMAsIII and were more frequently diabetic than the respective wild-type carriers, although the excess was not statistically significant. Odds ratios were 11.4 (95% confidence interval (CI) 2.2–58.8) and 8.8 (95% CI 1.6–47.3) for the combined effects of arsenic exposure >75th percentile and 287T and 4965C genotypes, respectively. Carriers of 287T and 4965C may produce more DMAsIII and be more likely to develop diabetes when exposed to arsenic.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (26)
CITATIONS (53)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....