Vitamin D levels and patient outcome in chronic kidney disease

• DOI: 10.1038/ki.2008.501
• Publication Date: 2008-10-08T12:06:12Z
• Authors: Pietro Ravani; Fabio Malberti; Giovanni Tripepi; Paola Pecchini; Sebastiano Cutrupi; Patrizia Pizzini; Francesca Mallamaci; Carmine Zoccali
• Keywords: cardiovascular risk; CKD progression; survival; 3. Good health; Survival Rate; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Nephrology; Predictive Value of Tests; Chronic Disease; CKD; Disease Progression; Humans; Kidney Diseases; 1,25OH vitamin D; Vitamin D; 25OH vitamin D; Follow-Up Studies; Glomerular Filtration Rate; Proportional Hazards Models

Vitamin D deficiency has been linked to cardiovascular disease and early mortality in patients on hemodialysis; however, it is not known if the same association exists at earlier stages of chronic kidney disease. To determine this we enrolled 168 consecutive new referrals to a chronic kidney disease clinic over a 2 year period and followed them for up to 6 years. All patients were clinically stable and had an estimated glomerular filtration rate (eGFR) at stage 2 or less and were without an imminent need for dialysis. Baseline 25-hydroxyvitamin D levels directly and significantly correlated with eGFR. After an average follow-up of 48 months, 48 patients started dialysis and 78 had died. In crude analyses, 25-hydroxyvitamin D predicted both time to death and end-stage renal disease. A dual-event Cox's model confirmed 25-hydroxyvitamin D as an independent predictor of study outcomes when adjusted for age, heart failure, smoking, C-reactive protein, albumin, phosphate, use of converting enzyme inhibitors or angiotensin receptor blockers, and eGFR. Our study shows that plasma 25-hydroxyvitamin D is an independent inverse predictor of disease progression and death in patients with stage 2-5 chronic kidney disease.