The transcriptional repressor HIC1 regulates intestinal immune homeostasis

• DOI: 10.1038/mi.2017.17
• Publication Date: 2017-03-22T15:27:13Z
• Authors: K. Burrows; F. Antignano; M. Bramhall; A. Chenery; S. Scheer; V. Korinek; T.M. Underhill; C. Zaph
• Keywords: Homeostasis; Lamina propria

The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant commensal microbes and food antigens. However, the molecular mechanisms regulate cell function in unclear. Here we identify POK/ZBTB family transcription factor hypermethylated cancer 1 (HIC1, ZBTB29) as central component of immunity inflammation intestine. HIC1 specifically expressed cells intestinal lamina propria (LP) steady state mice with T-cell-specific deletion have reduced numbers T LP. expression regulated by Vitamin A metabolite retinoic acid, raised on A-deficient diet lack HIC1-positive HIC1-deficient overproduce IL-17A vitro vivo, fail induce inflammation, identifying critical role for regulation T-cell microenvironment under both homeostatic inflammatory conditions.