Aberrant expression of CHFR in malignant peripheral nerve sheath tumors
Adult
Aged, 80 and over
Male
0301 basic medicine
Adolescent
Infant
Cell Cycle Proteins
Middle Aged
Immunohistochemistry
Nerve Sheath Neoplasms
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
03 medical and health sciences
Ki-67 Antigen
0302 clinical medicine
Cell Line, Tumor
Child, Preschool
Multivariate Analysis
Humans
Female
Child
Poly-ADP-Ribose Binding Proteins
Aged
DOI:
10.1038/modpathol.3800548
Publication Date:
2006-03-22T15:28:28Z
AUTHORS (10)
ABSTRACT
Mitotic checkpoint maintains genomic integrity before mitosis. Numerous observations have suggested that mitotic abnormalities produce chromosomal instability and aneuploidy. In MPNST, complex karyotypes showing numerical and structural aberrations have been described. 'Checkpoint with forkhead-associated domain and ring finger' (CHFR) was recently identified as defining a new early mitotic checkpoint. We examined the expression of CHFR in 96 cases of MPNST by immunohistochemical and molecular methods. We found reduced (score, < or = 3) expression of CHFR in 63 out of 96 (66%) cases of MPNST, and such alteration was significantly correlated with a high mitotic count, a high Ki-67-labeling index, and a poor prognosis. In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation.
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CITATIONS (22)
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