A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

• DOI: 10.1038/msb.2010.31
• Publication Date: 2010-06-08T18:14:53Z
• Authors: Celine Lefebvre; Presha Rajbhandari; Mariano J Alvarez; Pradeep Bandaru; Wei Keat Lim; Mai Sato; Kai Wang; Pavel Sumazin; Manjunath Kustagi; Brygida C Bisikirska; Katia Basso; Pedro Beltrao; Nevan Krogan; Jean Gautier; Riccardo Dalla‐Fa...; Andrea Califano
• Keywords: Interactome; FOXM1; Transcription; Gene regulatory network

Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals hierarchical, control module, where MYB FOXM1 act as synergistic master regulators proliferation germinal center (GC). Eighty percent genes jointly regulated by these transcription factors are activated GC, including those encoding proteins complex regulating DNA pre‐replication, replication, mitosis. These results indicate that HBCI analysis can be used for identification determinants major cell phenotypes provides paradigm general applicability to normal pathologic tissues.