Upgrading protein synthesis for synthetic biology

• DOI: 10.1038/nchembio.1339
• Publication Date: 2013-09-17T18:31:12Z
• Authors: Patrick O'Donoghue; Jiqiang Ling; Yane-Shih Wang; Dieter Söll
• Keywords: Synthetic Biology; Genetic Code; Protein Engineering

Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems will require re-engineering central components of the protein synthesis machinery on the basis of a solid mechanistic biochemical understanding of the synthetic process.