Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics

• DOI: 10.1038/ncomms1020
• Publication Date: 2010-06-01T14:54:43Z
• Authors: Ashley W. Seifert; Zhengui Zheng; Brandi K. Ormerod; Martin J. Cohn
• Keywords: External genitalia; Hair cycle

The faithful positioning and growth of cells during embryonic development is essential. In this study Seifertet al. demonstrate that inactivation Sonic Hedgehogduring the genital tubercle results in a prolonged G1 phase slower rate growth. During development, are instructed which position to occupy, they interpret these cues as differentiation programmes, expand patterns by hedgehog (Shh) specifies positional identity many organs; however, its role not well understood. study, we show Shh external genitalia extends cell cycle from 8.5 14.4 h, reduced ∼75%. Transient signalling establishes pattern tubercle; transcriptional levels regulators reduced. Consequently, length extended, leading fewer progenitor entering S-phase. Cell genes responded similarly limbs, suggesting may regulate similar mechanisms different organ systems. finding regulates number controlling specific phases identifies novel mechanism elaborates appendage development.